The Repairing Effect of GDF10 after Central Nervous System Injury

LIAO Haikang¹^,2,3, LIU Weiqin⁴, ZOU Zhenyou¹, YAO Hua¹^,3*

(¹Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical College, Guilin 541004, China; ²Key Laboratory of Alzheimer’s Disease of Zhejiang Province, Institute of Aging, Wenzhou Medical University, Wenzhou 325035, China; ³Institute of Neurology and Chemistry, Wenzhou University, Wenzhou 325035, China; ⁴Department of Neurosurgery, Ganzhou City People’s Hospital, Ganzhou 341000, China)

Abstract:

GDF10 (growth differentiation factor 10) is a superfamily member of TGFβ (transforming growth factor beta). GDF10 in normal tissue is rare or no expression. However, during the injury in the central nervous system, it has a significant rise. It may prompt for GDF10 as therapeutic targets. Recent studies show that GDF10 in the brain cortex area of peri-infarct can promote neural axonal sprouting after ischemia stroke. Moreover, GDF10 highly express after SCI (spinal cord injury) and protect neural function. Therefore, this article will summarize the research progress of GDF10 expression regulation and cell signaling pathways, especially the role of GDF10 after central nervous system injury, in order to explore the biological activity of GDF10 and its value in drug development and application basic research.

CSTR: 32200.14.cjcb.2021.10.0012