Advances in the Research of NAMPT and Age-Related Diseases
ZHANG Xiaojuan*, BAI Yujie, SUN Haixing, WU Dongying
NAMPT (nicotinamide phosphoribosyltransferase), the rate-limiting enzymes of the NAD+ biosynthesis in mammalian, is a controller for intracellular NAD+ levels. NAMPT mediated NAD+ biosynthesis plays an important role in energy metabolism, DNA repair, chromatin remodeling, cell senescence and immune cell function regulation. However, the circulating level of NAMPT decreases significantly with age, leading to age-related diseases including metabolic diseases, neurodegenerative diseases, aging and cancer. Recent studies have found that increasing NAD+ levels through adipose tissue overexpression of eNAMPT can prolong the healthy life of mice. Hence NAMPT-NAD+ is a promising anti-aging intervention pathway. A systematic review of the research progress on NAMPT and age-related diseases is presented. NAMPT, as a clinically significant molecule, has wide application prospects in the diagnosis, prognosis and treatment of age-related diseases.
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