Research Progress on the Relationship between TRPC6 and Cardiovascular Diseases
TAN Yuanjia, ZHANG Shizhong*
TRPC6 (transient receptor potential cation channel 6) is one of the members of transient receptor potential ion channels, which is a non-selective cation channel. TRPC6 is widely distributed in organs and tissues such as the brain, nerves, heart, blood vessels, lung, kidney, gastrointestinal tract, etc. It can be activated by osmotic pressure change, mechanical stimulation and diacylglycerol, and then participates in the pathophysiological processes of many diseases in the body. Studies have found that the disorder of TRPC6 is closely related to the pathogenesis of cardiovascular diseases, and the relationships between TRPC6 and cardiovascular diseases have become research hotspots. This article mainly introduces the structural characteristics of TRPC6 and the latest research progress in its relationship with cardiovascular system-related diseases.
CN
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