DONG Junli, ZHANG Bowen, XU Nan*, XI Yan*, CHEN Su*
Research Progresses on the Regulatory Mechanism of Histone Degradation
Histone is an important component of chromatin, and its content significantly affects the formation of higher structure, gene expression, DNA replication and other important life activities of chromatin. Protein degradation is an important mechanism for the regulation of histone content. Numerous studies have shown that the degradation of histone is closely related to the modification of its amino acid residues. Besides, histone degradation is closely correlated with its covalent modifications such as ubiquitination and acetylation. This review focuses on PTM (post-translational modification) of histone amino acid residues, introduces the relationship between histone degradation and modification of amino acid residues, and reviews the recent advances in this field.
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