Research Progress of Inhibiting Intestinal Pathogenic Bacteria Based on Quorum Sensing
ZHANG Peng1, WU Shengbo1, WU Hao1, WANG Manman1, QIAO Jianjun1,2, CAIYIN Qinggele1,2*
QS (quorum sensing) is a communication process between microbial cells that relies on the production, release and recognition of AIs(autoinducers), and plays an important role in the growth of microbes. In the intestinal environment, enteric pathogenic bacteria such as Salmonella typhimurium, Vibrio cholerae, Clostridium difficile, Escherichia coli and other intestinal pathogenic bacteria infect the host body and affect the normal immunometabolic process of the host body, triggering acute gastroenteritis, dysentery and other diseases. Traditional treatment regimens in which antibiotics cope with intercurrent infections caused by enteropathogenic bacteria have developed, but the misuse of antibiotics can lead to multi drug resistance in bacteria, which migrate and mutate at the genetic level. In recent years, more and more studies have shown that the QS system can be manipulated to regulate the formation of bacterial biofilm, the production of virulence factors, and the inhibition of drug resistance. This paper begins with a summary of the working paths of several typical bacterial QS systems; and several QS therapeutic strategies for common enteropathogenic bacteria are reviewed in the hope of providing some references for the development of novel treatment options and related enteropathogenic inhibitors for intestinal diseases.
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