Recent Advances in the Role of Wnt Signaling Pathway in Hair Follicle Formation and Growth Induced by Dermal Papilla Cells
YUAN Mu, HU Xueting, XU Xiang*
Treatment of large area alopecia is a difficult problem at present. In vitro culture and transplantation of hair follicles is a potential treatment program, but there are few successful cases in clinical practice. The regulation mechanism of hair follicle formation and growth is very complex, and it is difficult to simulate in vitro culture. In the current research, hair follicle formation induced by hair follicle papilla cells is the main method of hair follicle culture in vitro, and Wnt signaling pathway plays a core role in the regulation of hair follicle formation and periodic regeneration induced by hair follicle papilla cells. This review summarizes the recent studies on the role of Wnt signaling pathway in follicle papilla cells induced follicle formation and growth cycle, and the new methods of hair follicle culture in vitro in recent years. It is hoped that in vitro culture combined with different culture methods and regulatory factors can provide new ideas and basis for clinical treatment of large area alopecia.
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