Functions of KAP1 and Its Research Progress in Diseases

YAN Tianqing¹, MA Ping^1,2, QI Suhua¹, WANG Wan^1,2*

(¹School of Medical Technology, Xuzhou Medical University, Xuzhou Key Laboratory of Inspection and Diagnostics, Xuzhou 221004, China; ²Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China)

Abstract:

KAP1 (KRAB-associated protein 1), also called TIF1β (transcriptional intermediary factor 1β) or TRIM28 (tripartite motif-containing protein 28), is a scaffold molecule involved in formation of many gene transcriptional regulatory complexes. KAP1 participates in many physiological and pathological processes, such as immune response, early embryonic development and stem gene expression, DNA damage repairation, tumor development and so on. KAP1 has a variety of post-translational modifications, such as phosphorylation and acetylation, and is involved in protein ubiquitination, DNA methylation, histone methylation, and deacetylation, which plays an important role in the function of KAP1. This paper summarizes the function of KAP1 and its research progress in diseases, hoping to provide guidance for molecular therapy with KAP1 as the target.

CSTR: 32200.14.cjcb.2021.07.0026