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The Role of Claudin-5 Mediated BBB Dysfunction in Cerebral Ischemia Reperfusion
GUO Yanqin, ZHAO Hang, CHEN Jing, HE Zhi*
(Medical College of Three Gorges University, Yichang 443002, China)
Abstract:
As a transmembrane protein and an important adhesion molecule of tight junctions between brain endothelial cells, Claudin-5 participates in the composition of the blood-brain barrier and regulates its permeability and tightness. Also it mediates the occurrence and development of cerebral ischemia reperfusion injury. This article reviews the structure and function of Claudin-5, and its role in cerebral ischemia reperfusion, providing a new theoretical basis for the treatment of cerebral ischemia reperfusion injury.
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