Research Progress on Abnormal Expression of miRNAs in the Metastasis Mechanism of Cervical Cancer

WANG Weiyu¹, SHEN Ying¹, GUO Ying², HAN Fengjuan²*

(¹Heilongjiang University of Chinese Medicine, Harbin 150040, China; ²The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040, China)

Abstract:

The early metastasis of primary tumor of CC (cervical cancer) is one of the main reasons leading to poor prognosis and response. Therefore, it’s very important to comprehensively understand the metastasis mechanism of cervical cancer. miRNAs (microRNAs) are a kind of small non-coding RNAs that regulate gene expression through post-transcriptional silencing, playing an important role in the occurrence and development of tumors. miRNAs affect the metastasis of cervical cancer by regulating EMT (epithelial-mesenchymal transition), microvascular formation, degradation of ECM (extracellular matrix) and cytoskeletal remodeling. This article reviews the research progress of miRNAs in the metastasis mechanism of cervical cancer, in order to provide a reference for the development of targeted drugs against cervical cancer metastasis based on miRNAs.

CSTR: 32200.14.cjcb.2021.07.0020