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Roles of Stem Cells in Vascular Remodeling


CHEN Kai, XU Qingbo*

(Department of Cardiology, the First Affiliated Hospital of Zhejiang University, School of Medicine, Zhejiang University, Hangzhou 310003, China)
Abstract:

Stem/progenitor cells in the vessel wall and surrounding adipose tissue are important in vascular development and disease progression. Accumulating evidences show that these cells are involved in the repair of vascular injury and the process of vascular remodeling. It is likely that the proportion of their participation in vascular remodeling is determined by the severity of vascular injury. This article reviews the history of vascular stem cell research, and summarizes the latest progress of its involvement in the process of vascular remodeling. Furthermore, the relevant research results of current research were focused, aiming to clarify the different roles of stem cells in vascular diseases and put forward some constructive suggestions for future research directions.


CSTR: 32200.14.cjcb.2021.07.0004