Expression and Regulation of TMEM16A in Epithelial Cells
YANG Wenjing, YU Bo*
TMEM16A (tranmenbrane protein 16A) is widely expressed in the body as a known CACC (calcium-activated chloride channel), which mediates many important physiological functions. In epithelial cells, TMEM16A can mediate membrane potential changes and fluid secretion through multiple reactions. In addition, TMEM16A expression is up-regulated in a variety of inflammation-related epithelial diseases, such as cystic fibrosis, asthma and acute pancreatitis; regulating TMEM16A expression and channel activity may be a potential strategy for the treatment of inflammation. Studying the expression and regulation mechanism of TMEM16A in epithelial cells is of great significance for elucidating the physiological and pathological functions of TMEM16A. Here, this artical reviewed the latest research progress of TMEM16A in epithelial cells.
CN
EN