Advances on the Correlation between Bone Marrow Adipocytes and Leukemia Development

TU Wenyan¹, XU Jiaye¹, HONG Yaonan¹, SHAO Keding², WU Dijiong¹^,3*

(¹The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou 310053, China; ²Office of Academic Research, Zhejiang Chinese Medical University, Hangzhou 310053, China; ³Department of Hematology, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, China)

Abstract:

BMAT (bone marrow adipose tissue) is a kind of adipose tissue that exists in the peripheral and distal bones of adults. The function of MAT was not fully clarified based on previous studies, most of which believed that it only played a role as spatial occupation, and showed as hypohematopoiesis. With the developing knowledge of bone marrow microenvironment, more and more studies found that adipocyte worked as endocrine organs and was related to the outcome of many diseases. Based on the current studies, abnormal metabolism of bone marrow adipocytes has been found in many types of leukemia (acute myeloid leukemia, acute lyphoctic leukemia, as well as chronic leukemia), which was believed to contribute to its development,
and have a significance on its prognosis. Better understanding the role of BMAT in hematologic disease, trying to figure out the interaction between bone marrow adipocytes and leukemic cells, and work on regulating the metabolism of BMAT may be of great significance in leukemia management in the near future.

CSTR: 32200.14.cjcb.2021.06.0020