Research Progress of CircRNA in Viral Infection and Related Disease Diagnosis
LI Jing, TENG Peiying, CHEN Wei*
circRNA (circular RNA), a novel type of non-coding RNA, is formed by the “back-splicing” of mRNA during post-transcriptional processing. Unlike the linear RNA, circRNA is covalently linked to form a closed circular structure without 5ʹ end cap or 3ʹ poly(A) tail. circRNA acts as a miRNA (microRNA) sponge and also plays a variety of functions in the process of cytogenesis. In addition, circRNA plays an important role in the process of immune regulation and is involved in the development of diseases. Therefore, the further research of circRNA can provide an important theoretical basis for the treatment of human diseases. In this review, a comprehensive overview on the biogenesis, classification, and functions of circRNA is provided. Especially, the regulatory mechanism of circRNA on viral infection and the research progress of circRNA as viral detection marker and drug target and drug target are mainly discussed, so as to provide reference basis and direction for the diagnosis of viral diseases.
CN
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