The Development and Application of Pancreatic Organoid Technology
MA Shuangyu, ZHAO Bingnan, WANG Qiong*
In the process of studying human biology and mechanisms underlying disease progression, animal models have played important roles. But in the meantime, their limitations also have gradually become prominent. The emerging human organoid technology has compensated for the insufficiency of animal models. Organoids mainly refer to 3D (three-dimensional) multicellular tissue cultures derived from stem cells, which mimic the corresponding in vivo organs. Organoid constructions have been achieved from several organs including the gastrointestinal tract, esophagus, liver, gallbladder, brain, bladder and so on. The pancreas is unique because it functions as both an exocrine gland and an endocrine gland. Currently, pancreatic duct and islet organoid technologies are under rapid development. However, how to build whole pancreatic organoids with complex structures is still challenging. This review will mainly discuss the latest research about pancreas development and organoid generation. In addition, the perspectives on the application and future studies of pancreatic organoids will also be provided here.
CN
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