Advances and Applications of Liver Organoids
WANG Yixian#, ZHU Yanjing#, WANG Hongyang*, CHEN Lei*
Liver is an important organ mediating various metabolic functions and also has high incidence of diseases. In recent years, the morbidity of liver diseases has been increasing gradually. Especially, primary hepatocellular carcinoma has become the second leading cause of cancer-related death worldwide. Thus, understanding the physiological functions of liver, developing practical experimental platform for liver physiological metabolism and disease progression researches, as well as establishing new strategies and methods for disease intervention in vitro can provide new ideas for the pathogenesis, early diagnosis and comprehensive treatment of liver diseases. This review discusses the recent progress of establishment, applications and technical bottlenecks for liver organoids and their potential advances for exploring the underlying mechanism in liver diseases.
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