Applications of Organoids in Regenerative Medicine

LI Xiaomeng¹^#, GUAN Ruoyu¹^#, GAO Jianjun¹, HUA Guoqiang¹^,2*

(¹Institute of Radiation Medicine, Fudan University, Shanghai 200032, China; ²Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai 200032, China)

Abstract:

Organoids, known as three-dimensional micro-organs obtained by culturing stems cells in matrix materials in vitro, are highly similar to the source tissues and organs. The organoid technology provides a new powerful research model and technical tools for basic research, drug screening and regenerative medicine. The aim of regenerative medicine is to help tissues or organs to restore their normal physiological functions. By combining with tissue engineering or genetic engineering, organoids provide a new source of transplants for regenerative medicine. This review presents the applications of organoids in regenerative medicine and discusses the main challenges in this field.

CSTR: 32200.14.cjcb.2021.06.0002