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Functions of Endogenous Gaseous Hydrogen Sulfide in Central Nervous System
Li-Xing Zhang*, Xiao-Xia Wang1, Shui-Jiang Song2, Wei-Jun Jin
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China;1College of Medicine, University of Saskatchewan, Saskatoon, Canada; 2 Department of Neurology, the Second Hospital,Colleg
Abstract:
Endogenous hydrogen sulfide (H2S) can increase the production of cAMP， potentiate the exciting postsynaptic potential mediated by NMDA receptor and enhance the induction of hippocampal long-term potentiation. In central nervouse system， H2S functions as a neuromodulator as well as a neuroprotectant. H2S itself does not rescue cells from oxidative stress; instead it protects neurons by increasing the level of a major and potent antioxidant， reduced glutathione. The study of H2S is very new. Understanding the mechanism of its physiological function may provide a new insight into its neurons protection.
Endogenous hydrogen sulfide (H2S) can increase the production of cAMP， potentiate the exciting postsynaptic potential mediated by NMDA receptor and enhance the induction of hippocampal long-term potentiation. In central nervouse system， H2S functions as a neuromodulator as well as a neuroprotectant. H2S itself does not rescue cells from oxidative stress; instead it protects neurons by increasing the level of a major and potent antioxidant， reduced glutathione. The study of H2S is very new. Understanding the mechanism of its physiological function may provide a new insight into its neurons protection.
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