Novel Intestinal Mesenchymal Stromal Cell MRISC Regulates Intestinal Stem Cell upon Damage-Induced Tissue Repair and Inflammation
WU Ningbo, SUN Hongxiang, TAN Jianmei, SU Bing*
Inflammation and tissue damage could rapidly stimulate intestinal stem cell proliferation and promote tissue regeneration. Intestinal mesenchymal stromal cell, one of the key components of intestinal micro-environment, plays an essential regulatory role in this process. With the advancement of single cell sequencing technologies, researchers revealed intestinal mesenchymal stromal cells as a complex and highly heterogeneous cell population. Currently, the gene signature, spatial distribution, potential function, cellular and molecular regulatory mechanisms of these distinctive stromal cell populations are still poorly understood. This paper revisited the course of MRISC (MAP3K2-regulated intestinal stromal cell) discovery, and described the role and mechanism of MRISC involved in intestinal epithelial repair by specifically regulating the R-spondin1-Wnt signal of the intestinal stem cell niche during intestinal inflammation and injury. This work provided new insights in application of MAPK signal
perturbation to the research and therapies of intestinal diseases.
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