The Role of Tim-3 in Breast Cancer

Breast cancer is the most common cancer among women, with a very high mortality rate. Although many advances have been made in the treatment of breast cancer, its high degree of heterogeneity and ability of invasion and metastasis make the clinical urgent need for new treatment strategies and ideas. With the rise of immune checkpoint blocking therapy, Tim-3 (T cell immunoglobulin and mucin domain molecule 3) entered people’s field of vision. Tim-3, as an immune checkpoint molecule, plays an important role in the development of breast cancer. Tim-3 can be used to evaluate the effect of breast cancer treatment. Anti-Tim-3 antibodies and other inhibitors have been effective in the treatment of breast cancer in preclinical studies. This review summarizes the expression mechanism of Tim-3 and its role in breast cancer, and discusses the basic principles of Tim-3 as a breast cancer treatment target and potential treatment options for Tim-3 in breast cancer.

CSTR: 32200.14.cjcb.2021.04.0023