Advances in the Structure and Function of Bromodomain-Containing Protein 2

ZHOU Lei^1,2, HAN Yifan^1,2, DUAN Zhiqiang^1,2*

(¹Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountains Region, Ministry of Education (Guizhou University)/Key Laboratory of Animal Genetics, Breeding and Reproduction in Guizhou Province, Guiyang 550025, China; ²College of Animal Sciences, Guizhou University, Guiyang 550025, China)

Abstract:

BRD2 (bromodomain-containing protein 2) is a member of the bromodomain and extra-terminal domain family, which has two tandem bromodomains and one extra-terminal domain. BRD2 protein can specifically bind histone acetylated lysine and participate in gene transcriptional regulation, chromatin remodeling, cell proliferation and apoptosis and other biological activities. Recently, studies have shown that BRD2 regulates gene transcription, cell cycle, neurodevelopment, inflammation and lipogenesis through the epigenetic interaction between bromodomain and acetylated histone in the process of cell proliferation and differentiation, and also plays important roles in promoting tumor cell proliferation and mediating potential virus infection and replication. This review focuses on the structural characteristics and cellular functions of BRD2 and also the mechanisms of BRD2-participated in virus replication, which provide useful references for further studying the functions of BRD2.

CSTR: 32200.14.cjcb.2021.04.0019