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Intrabody and Its Latest Advances
Mei-Ya Hong, Dong-Yun Zeng, Xing-Guo Gong*
Institute of Biomacromolecule and Enzymatic Engineering, Zhejiang University, Hangzhou 310027, China
Abstract: As we all know， intrabody is a new engineering antibody which is expressed in cell and oriented in subcellular area. Due to ScFv gene's simple structure， it is amiable to expressed in cell and convenient for in vitro recombination operation. Accordingly current research on intrabody concentrate on ScFv. As a new gene therapy tool， intrabody brings forth extensive application foreground in the aspects of tumor gene therapy and human HIV gene therapy's experimental study and potential clinical therapy. At the same time， intrabody is also served as a study tool for analyse the function of target protein， and it's an effective complementarity to the traditional "gene knock-out"genetically modified animal. This article summarizes intrabody's latest research advances from its design and the selection of vector， tumor gene therapy and human HIV gene therapy.
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