The Role of Adhesion Molecule CD24 in Tumor Metastasis

Abstract: Glycosylphosphatidylinositol-anchored membrane protein CD24 is a ligand of P-selectin and plays a role in B-cell development and neurogenesis. Over the last years， a large body of literature has implicated CD24 overexpression in tumorigenesis and progression. Some investigator showed that ectopic CD24 expression could be sufficient to promote tumor growth and metastasis in experimental animals. Enhanced CD24 expression correlating with prognosis， survival rate and clinical pathological parameter of tumor patients has been reported for a number of types of cancer， including renal cell carcinoma， small cell lung carcinoma， nasopharyngeal carcinoma， pancreatic carcinoma and neural tumors. Therefore， these investigations will help us to elucidate the molecular mechanisms of tumor progression. And furthermore， it could lead to the development of anti-cancer drugs and new therapeutic approaches.
    

CSTR: 32200.14.cjcb.2006.03.0013