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Progress of Regulatory Relationships between RNA Binding Protein and Non-Coding RNA

NI Shujing^1,2, XU Meiqian^1,2, CHEN Chen^1,2, WANG Linglin^1,2, ZHU Tingyan^1,2, YI Tianfei^1,2,
GIMILIGULI·Aini^1,2, LIAO Qi^1,2*

(¹Department of Preventative Medicine, Medicine School of Ningbo University, Ningbo 315211, China; ²Zhejiang Key Laboratory of Pathophysiology, Medicine School of Ningbo University, Ningbo 315211, China)

Abstract:

In recent years, more and more studies have shown that RBP (RNA binding protein) and various
types of ncRNAs (noncoding RNAs) have mutual regulatory relationships. The interactions between RBP and ncRNA have diverse mechanisms. On one hand, RBP can regulate the biosynthesis, stability and function of ncRNA; on the other hand, ncRNA can also affect the function and structure of RBP. At the same time, the interaction between RBP and ncRNAs also plays an important role in the regulation of other target genes, therefore participating in many biological processes, such as tissue development, metabolic diseases, neurodegenerative diseases, antiviral immunity and various kinds of cancers. This review focuses on the research progress of the regulation mechanisms between RBP and several common kinds of ncRNAs, including miRNA, lncRNA, and circRNA.

CSTR: 32200.14.cjcb.2021.01.0031