Recent Research Progress of Transcription Factor PU.1
TAN Ming, LI Wen, SUN Yingning*
Transcription factor PU.1 is one of the members of the ETS transcription factor family (E26
transformation-specific family), which plays crucial roles in diverse arrays of various systems in the organism. The research in recent years has found that PU.1 not only plays a role in the determination and differentiation of hematopoietic lineages, but also functions in body immunity, adipogenesis, tissue fibrosis, and neurodevelopment. PU.1 and multiple target genes form a complex regulatory network in hematopoietic and immune system, and PU.1 is regulated by histone modification and epigenetics such as non-coding RNA. PU.1 participates in multiple processes such as cell proliferation and differentiation, which has certain significance for maintaining cell homeostasis. In addition, PU.1 is associated with the occurrence of erythrocyte leukemia, pre-B cell acute lymphocytic leukemia, acute myeloid leukemia, allergic disease, rheumatoid arthritis, obesity-related diseases, osteopetrosis, glioma and other diseases. This review summarizes the latest research progress of PU.1 from the functional aspect, hoping to provide new ideas for the follow-up research of PU.1 and ETS family.
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