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Research Progress on Tropomyosin-Related Kinase B in Tumors
WANG Qian, HU Xuefeng*
(Fujian Key Laboratory of Development and Neurobiology, College of Life Sciences, Fujian Normal University, Fuzhou 350117, China)
Abstract:
TrkB (tropomyosin-related kinase B), a neurotrophic tyrosine receptor kinase, regulates cell differentiation, proliferation, apoptosis and migration by MAPK (mitogen-activated protein kinases), PLC-γ (phospholipase C-γ), PI3K (phosphatidylinositol 3-kinase), JAK (Janus kinase)/STAT3 (signal transducer and activator of transcription 3) and Wnt/β-catenin signaling pathways. The gene fusion, protein overexpression and single nucleotide changes of TrkB are strongly related to cancers. Here, the study reviewd the biological characteristics related signaling pathways and mechanism in tumors of TrkB.
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