Recent Progress of Differences between Left-Sided and Right-Sided Colon Cancer on Multi-Omics Molecular Characteristics
CC (colon cancer) is a type of the common malignant tumor with high morbidity and mortality.
Based on the anatomical location of primary cancer site, CC can be divided into LCC (left-sided colon cancer) and RCC (right-sided colon cancer). There is a large heterogenicity between the patients with LCC and RCC in clinical characteristics. Due to the development of biological technology and sequencing technology, more and more studies have been conducted to identify the differences of molecular characteristics and microenvironment between LCC and RCC through multi-omics approach during the last decade. And these findings are used to guide the treatment and prognosis of CC patients. This review summarizes the recent progress of distinct molecular characteristics and treatment between LCC and RCC patients from the views of gene mutation, gene expression, miRNA expression, DNA methylation, immune microenvironment, immunotherapy and consensus molecular subtypes.
CN
EN