The Non-Cell Cycle Regulating Function of CDK2 in Tumor
LING Neng, LIU Yan, YE Mao*
CDK2 (Cyclin-dependent kinase 2), a member of Cyclin-dependent kinase family, acts as the
core regulator of eukaryotic cell cycle progression and drives G1-S and S-G2 transition. Emerging evidence indicates that the role of CDK2 is not necessary for mammalian cell cycle regulation. However, CDK2 is involved in various oncogenic signaling pathways. Its dysregulation causes uncontrolled proliferation of tumor cells. In addition to the cell cycle regulation, CDK2 plays a key role in a variety of biological functions including cell differentiation, senescence, apoptosis, and chromosome instability, which contributes to tumor formation and progression. This review summarizes the recent advances in the non-cell cycle regulating function of CDK2 in tumors.
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