Advances in the Molecular Mechanism of Pyroptosis

Involved in the Occurrence of Tumors

Pyroptosis is a new lytic, pro-inflammatory programmed cell death characterized by cell swelling,
plasma membrane perforation, and release of inflammatory small molecules. It is a programmed cell death model mediated by cysteine aspartic acid specific protein kinase 1, 4, 5, 11, which mainly depends on the poreforming activity of Gasdermin protein family. At present, it is found that pyroptosis participates in the occurrence and development of many diseases, especially its dual functions of promoting and inhibiting the formation of tumor and tumor microenvironment. It makes pyroptosis becomes one of the latest hot spots in the research of anti-tumor drugs. In this paper, the molecular mechanism of cell pyrosis in tumorigenesis is reviewed. The significance of pyroptosis in cancer treatment is discussed in order to provide a reference for targeted therapy of tumors.

CSTR: 32200.14.cjcb.2021.01.0024