Research Progresses of Acetylation of Key Protein in Cell Autophagy and the Treatment of Related Diseases

JIN Luqi¹, YAN Chunlan², LIU Weigang¹, WAN Qun³, DING Shiping¹*

(¹Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China; ²Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China; ³the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China)

Abstract:

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. In the past decade, the molecular mechanisms underlying autophagy have been extensively studied. Importantly, the key role of acetylated autophagy complexes has been identified and elucidated. This review systematically summarizes the current knowledge of acetylation of the key autophagy complexes, the function of these modifications, and their therapeutic functional implications in cancer and neurodegenerative diseases. In conclusion, acetylation has become the hot talk of autophagy researches. Understanding the acetylation of the autophagy machinery offers a unique window for the control of autophagy-related diseases.

CSTR: 32200.14.cjcb.2021.01.0023