Research Progress of Ketone Body Related Mechanism of Exercise Improving Alzheimer’s Disease
SHEN Chenfei, LOU Shujie*
AD (Alzheimer’s disease) is a kind of neurodegenerative disease that mostly occurs in elderly
people. Currently, there is no effective drug for AD, but ketone body and exercise can protect the brain and effectively delay the pathological process of AD. As the most abundant ketone body in mammals, BHB (β-hydroxybutyrate) can be used not only as an alternative energy substance but also as a signaling molecule. The increase of BHB in brain after exercise can also promote the expression of BDNF (brain-derived neurotrophic factor), which is of great significance in improving the cognition and memory of AD patients. The ketone body-related mechanism of exercise improving AD is unclear. This review summarizes the latest research progress on the effects of exercise-mediated BHB on AD, and aims to provide a new idea for the prevention, alleviation and treatment of AD from the perspective of exercise-ketone bodies.
CN
EN