The Crosstalk between Autophagy and Ferroptosis

Autophagy and ferroptosis are two forms of RCD (regulated cell death). Autophagy supplies
nutrients for the synthesis of essential proteins during starvation, and thus helps to extend cell survival. However, excess autophagy can destroy essential cellular components and lead to cell death. Ferroptosis is a newly identified RCD which depends on the iron accumulation and lipid peroxidation. The main features of ferroptosis are significantly distinguished from autophagy in terms of morphology, biochemistry and genetics. Recently, extensive evidences have shown that there is a crosstalk between these two forms of RCDs. Studies have demonstrated that activation of ferroptosis is dependent on the induction of autophagy. Additionally, many ferroptosis regulators have been identified as potential regulators of autophagy. This review highlights the crosstalk mechanisms between autophagy and ferroptosis at the molecular level.

CSTR: 32200.14.cjcb.2021.01.0018