Effects of Exercise on the Signaling Pathway of Mitochondrial-Mediated Skeletal Muscle’s Apoptosis

LIN Haiqi¹, CHEN Liang², WANG Zhen³, LIN Wentao⁴*, YUAN Yu⁴*

(¹College of Physical Education, South China University of Technology, Guangzhou 510641, China; ²Institute of Physical Education and Health, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; ³Guang Dong Youth Vocational College, Guangzhou 510545, China; ⁴School of Sports and Health, Guangzhou Sport University, Guangzhou 510500, China)

Abstract:

Apoptosis is a programmed cell death. Its signal transduction pathway can be divided into exogenous and endogenous pathways. Mitochondria plays an important role in the intrinsic apoptotic pathway. It has been found that exercise can regulate the process of mitochondrial mediated apoptosis of skeletal muscle cells. However, the mechanism of motor regulation of mitochondria-mediated skeletal muscle cell apoptosis signaling pathway affecting the cellular biological processes has not been clarified. This article mainly elaborates the signal transduction pathway of mitochondria-mediated apoptosis and the mechanism of exercise regulating the signal transduction pathway, aiming to provide a theoretical basis for exercise intervention for the prevention and treatment of mitochondrial-related metabolic diseases.

CSTR: 32200.14.cjcb.2021.01.0015