The Roles of E3 Adaptor SPOP and MDM2 in the DNA Damage Repair
LIN Zihan, CAO Xinyi, JIN Xiaofeng*
DDR (DNA damage repair) is the basis for maintaining the stability and integrity of the cell genome. More and more researches find that E3 ubiquitin-protein ligase plays an important role in DDR. This review analyzes the mechanisms of DDR, the relationships between DDR and diseases, and the roles of E3 ubiquitin-protein ligases, such as MDM2 and SPOP, in DDR. Moreover, the molecular mechanisms of DDR in two key signal pathways were summarized, including E3 ubiquitin-protein ligase SPOP and ATM (ataxia-telangiectasia mutated)/ATR (ATM and Rad3-related) pathway, as well as E3 ubiquitin-protein ligase MDM2 and p53 pathway. This review looks forward to providing new ideas for DDR.
CN
EN