The Mechanism of STAT3 in the Development of Colorectal Cancer
LI Feifei , ZHANG Zhiwei, YU Hongjie, ZHANG Xiaoxiao*
CRC (colorectal cancer) is one of the most common malignant tumors in the digestive tract. The clinical treatment strategy is based on surgical resection combined with postoperative chemotherapy. STAT3 (signal transducer and activator of transcription 3) is an important transcription factor in cells, and is composed of 750-795 amino acids (about 92 kDa). The occurrence and development of colorectal cancer are related to several abnormal activated signaling pathways. A large number of studies have shown that STAT3, which is abnormally highly activated in colorectal cancer tissues, can promote cell proliferation, inhibit apoptosis, and mediate angiogenesis, as well as tumor invasion and metastasis, etc. In recent years, it has become a research hotspot in colorectal cancer and a potential target for diagnosis and treatment of colorectal cancer. In this paper, recent studies on STAT3 and the status of STAT3 in colorectal tumors are reviewed.
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