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Parthenogenetic Stem Cells and Parthenogenesis in Mammals
FANG Yuan1, CHAI Mengjia1, KONG Qingran1,2, LIU Zhonghua1*
(1Key Laboratory of Animal Cellular and Genetic Engineering of Heilongjiang Province, College of Life Science, Northeast Agricultural University, Harbin 150030, China; 2Key Laboratory of Laboratory Medicine, College of Laboratory Medicine and Life Science, Ministry of Education, Wenzhou Medical University, Wenzhou 325000, China)
Abstract:
As a research hotspot in recent years, pESCs (parthenogenetic embryonic stem cells) derive from unfertilized parthenogenetic embryos. pESCs not only have the similar abilities of pluripotency and self-renewal as ESCs (embryonic stem cells), but also have the advantages of wide sources, high acquisition efficiency and low tumorigenic ability. This review described the specific characteristics of pESCs in histocompatibility and genomic imprinting, and summarized its application in parthenogenesis, and prospected its value in genetic diseases and clinical research.
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