Recent Progress in Parthanatos—a New Form of Cell Death

YANG Xiyao, ZHANG Na, YANG Yang, XU Tianrui*, An Shu*

(Key Laboratory of Target Drug Screening and Utilization of Yunnan Province, College of Life Sciences and Technology, Kunming University of Science and Technology, Kunming 650000, China)

Abstract:

As a new form of regulated cell death, parthanatos occurs by a mechanism different from apoptosis, and plays a key role in the pathological process of neurodegenerative diseases, stroke, glutamate-induced excitotoxicity, ROS (reactive oxygen species)-induced injury and tumors. Because the abnormal activation of PARP-1 is required for the induction of parthanatos, parthanatos is also known as PARP-1-mediated apoptosis. Additionally, AIF (apoptosis inducing factor) and MIF (macrophage migration inhibitory factor) are also the two key factors in the process of parthanatos. This review will describe the molecular mechanism of parthanatos and discuss its influence on the occurrence and development of some diseases.

CSTR: 32200.14.cjcb.2021.01.0006