Research Advances on Innate Lymphoid Cells in Lipid Metabolism

HE Anfang¹, XU Wei², WU Mengmeng¹, JIANG Peicheng³, YANG Dongqin¹*

(¹Department of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai 200040, China; ²Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200030, China; ³Department of Gastroenterology, Jinshan Hospital, Fudan University, Shanghai 200540, China)

Abstract:

Obesity and obesity-associated metabolic diseases have become worldwide health problems as a result of changes in nutritional conditions and lifestyles. A series of studies on energy storage and consumption have demonstrated that excess and ectopic accumulation of lipids promote chronic inflammation and remodeling of metabolic tissues, which leads to a new direction of metabolic diseases and immunity. ILCs (innate lymphoid cells) are newly discovered tissue-resident immune cells. ILCs have been reported to play a role in the maintenance of steady-state energy metabolism and the development of chronic inflammation in obese tissues, which makes them the rising star in the field of lipid metabolism. This review will discuss the research advances in chronic inflammation of adipose tissue under obesity highlighting the role of ILCs in energy metabolism and the molecular mechanism of regulation, thus providing scientific support for the transformation of ILCs in the treatment of metabolic diseases.

CSTR: 32200.14.cjcb.2021.01.0005