Application of Single-Cell RNA Sequencing Technology in Cell Classification
YANG Jiafeng, CHEN Penglu, GONG Xi*
The cell types of multicellular organisms are numerous and complex, and inter-cell heterogeneity is prevalent. The emerging scRNA-seq (single-cell RNA sequencing) technology is of great importance in researching the transcription levels of individual cells. This technology produces a transcription profile from thousands of parallel cells, reveals the differential expression of single cell genome, and reflects the heterogeneity between cells. This technology identifies different types of cells and forms a cell map of tissues or organs. Having a significant role in bioscience and clinical medicine, scRNA-seq technology is becoming a focal point of life science research. Based on the detailed description and comparison of scRNA-seq sequencing platform, this review focuses on the exploration of cell types in nervous system and immune system, and summarizes the application of scRNA-seq and space transcriptome technology.
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