Regulatory Effects of HIF-1α in Bone Cell Metabolism and Bone Diseases

LIU Lifei¹^,2, TONG Xiaoyang¹, GUO Jianmin¹, CHEN Xi³, YANG Jie⁴*

(¹School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China;²Rehabilitation Department,People’s Hospital of China Medical University, People’s Hospital of Liaoning Province, Shenyang 110016, China;³School of Sports Science, Wenzhou Medical University, Wenzhou 325035, China;⁴Affiliated School of Elite Sport, Shanghai University of Sport, Shanghai 200438, China)

Abstract:

HIF-1α (hypoxia-inducible factor-1α) is a key factor that regulates the response of cells to hypoxia. It can be activated when the oxygen content is reduced, and regulates various physiological activities such as oxygen metabolism and glycolysis. Bone metabolism mainly includes bone formation and bone resorption, both of which are regulated by various factors such as oxygen concentration. HIF-1α plays an important role in the regulation of cell metabolism, as well as bone tissue physiology and pathological processes, which can increase the hypoxia tolerance of bone tissue, and regulate bone formation and mineralization. This article mainly reviews the physiological regulation process of HIF-1α on the metabolism and angiogenesis of osteoblasts, osteoclasts, bone marrow mesenchymal stem cells, chondrocytes and other bone cells. The effects of HIF-1α on the formation of bone vessels, bone metastasis, femoral head necrosis and heterotopic ossification are also reviewed. This review provides a theoretical reference for exploring the regulation of HIF-1α on bone metabolism and the treatment of related diseases.

CSTR: 32200.14.cjcb.2021.02.0024