The Dual Role of PPARγ in Tumors
GUO Xin, ZONG Huanhuan, LI Duda, YU Yuyang, HOU Kailong, JIA Shuting*
PPARγ (peroxisome proliferator-activated receptor γ) is a ligand-dependent nuclear transcription factor and belongs to type II nuclear hormone receptor superfamily. Previous studies focused on the role of PPARγ in regulating lipid metabolism, glucose metabolism, immune inflammation, cell proliferation and differentiation. With the deepening of research, the role of PPARγ in tumors is becoming more and more clear. Previous reports mostly focused on the tumor-inhibiting effect of PPARγ, but recent reports on its promotion of tumors were also increasing. This article summarized the latest reports of PPARγ in tumors and discussed its dual roles in inhibiting and promoting tumor development.
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