Home > Browse Issues > Vol.28 No.3
Function of PPAR-g and Related Signaling Pathways
Yong-Xi Chen, Wei-Ming Wang, Tong Zhou, Nan Chen*
Department of Nephrology, Ruijing Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200032
Abstract: Peroxisome proliferater-activated receptor (PPAR) is among nuclear transcription factors superfamily and is activated by ligand. PPAR has three subtypes which are PPAR-a， PPAR-b/d and PPAR-g. Among these subtypes， PPAR-g has been thoroughly studied. PPAR-g inhibits inflammation by blocking JAK-STAT， activator protein-1 (AP-1)， NF-kB， nuclear factor of activated T cells (NFAT) signaling pathways. It ameliorates sclerosis by inhibiting foam cell differentiating， inflammation and cell proliferation. It maintains glucose homeostasis by PI3K， leptin， adiponectin signaling pathway. It inhibits tumor cells growth by mediating cell cycles. Also， it is closely related to obesity by participating in adipocytes differentiation. Thorough understanding of those signaling pathways and interaction of relevant cytokines might help us while treating relevant diseases.
CN
EN