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The Role of Slit/Robo Signal in Tumor Development
Ting Wu, Wei-Zhang Wang, Jian-Guo Geng1, Li-Jing Wang*
Institute of Basic Medical Sciences, School of Basic Courses, Guangdong Pharmaceutical University, Guangzhou 510006, China; 1Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, S
Abstract: Slit/Robo signal as neuronal guidance factor plays important roles in guiding axon growth and rejecting neuronal migration during the development of the nervous system. Furthermore， this signal also functions as a suppressor of leukocyte chemotaxis and an attractor of angiogenesis in development phase. Currently， most investigations focused on Slit/Robo signal in the central nervous system development. However， the role of this signal in carcinogenesis remained unknown. We review here the evidence for a role for Slit/Robo signal in cancer and focus on its role in tumor angiogenesis， cell migration and discuss the signaling pathways downstream of it， giving a new insight in the significance of Slit/Robo signal as a potential therapeutic target for cancer therapy.
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