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Advances in the Functions of NANOG in Mammalian Early Embryonic Development and Stem Cells
CHAI Zhuang, LIU Zhonghua*
(College of Life Science, Northeast Agricultural University, Harbin 150030, China)
Abstract:
Early embryonic development and stem cell pluripotency in mammals are regulated by gene-regulatory networks of transcription factors. The master transcription factor NANOG, that is found in embryonic stem cells in 2003 is the central transcription factor in gene-regulatory networks and is crucial for the second lineage segregation and establishment of ground-state pluripotency. Based on the biological characteristics of NANOG, the paper summarizes the functions of NANOG in early embryonic development, embryonic stem cells and induced pluripotent stem cells.
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