Advances in Research on Potential Targets of Radiation-Induced Bystander Effects Injury

ZHOU Gucheng¹, ZHANG Liying^1,2, ZHANG Yiming¹ , ZHOU Ting¹, LI Yangyang¹, NIU Fan¹, LIU Yongqi^1,2*

(¹Provincial-Level Key Laboratory for Molecular Medicine of Major Diseases and Study on Prevention and Treatment of Traditional Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, China; ²Key Laboratory of Ministry of Education Department of Lanzhou province and Dunhuang medical transformation, Gansu University of Chinese medicine, Lanzhou 730000, China)

Abstract:

Radiotherapy is one of the commonly used methods for the treatment of malignant tumors. But during the process of radiotherapy, not only the tumor cells are killed, but the normal tissue around the tumor is also damaged, which is called RIBE (radiation-induced bystander effects). Modern studies have shown that the generation of RIBE is mediated by gap junctions and soluble cell signaling molecules, including Cx (Connexin), CTSB (cathepsin B), TGF-β (transforming growth factor-β), TNF-α (tumor necrosis factor-α), IL-6 (interleukin-6), IL-8 (interleukin-8), ROS (reactive oxygen species) and nitrogen oxides. This article summarizes the drugs for these key targets and the key nodes of related cell signaling pathways, and further compares and analyzes their advantages and disadvantages. It will provide some clues for the selection of potential target drugs for side effects caused by clinical tumor radiotherapy.

CSTR: 32200.14.cjcb.2021.01.0002