Research Progress on Regulation of Pseudomonas aeruginosa Biofilm by c-di-GMP
GU Weixuan*
Pseudomonas aeruginosa biofilms are complex membrane-like aggregate consisting of surfaceattached cells and extracellular substances secreted by them. Pseudomonas aeruginosa that infects human has stronger multi-drug resistance and immune escape ability than those planktonic cells after the formation of biofilms, which increase the difficulty of treatment. Meanwhile, biofilms can also cause serious harm to medical, food, industry, agriculture and other fields. Understanding the regulation mechanism during the formation of biofilm is of great significance to the prevention of biofilms. As a second messenger widely found in bacteria, c-di-GMP (cyclic diguanosine monophosphate) plays an important role in regulating the formation of biofilms. Therefore, this paper makes a summary on the research progress of the regulation of c-di-GMP on biofilms in recent years, focusing on bacterial motility, exopolysaccharide expression and biofilms diffusion during biofilm formation. Thereby, the paper provides theoretical basis for the prevention and control of biofilms through c-di-GMP.
CN
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