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Application of Single Cell Sequencing Technology in Adipose Tissue
HU Fan, YANG Ying*
(Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200030, China)
Abstract:
Adipose tissue is composed of different types and functions of cells, showing complex heterogeneity. Single cell transcriptome sequencing technology provides an important tool for deconvolving cellular heterogeneity. The current review summarizes the application of single cell sequencing in adipose tissue, including adipocyte heterogeneity, the crosstalk between immune cells and adipocytes, and the pseudotime analysis of adipocyte differentiation, aiming to address the important role and significance of this technology in the study of adipose tissue and apply it to metabolic diseases.
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