Advances in Cell Models of Fatty Liver Disease

FENG Qiuqi¹, REN Guoyan^1*, QIAO Xiangjun², LIU Jia³, XIA Kai³

(¹College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471003, China; ²Port Bureau Of Zhengzhou Airport Economic Integrated Experimental Zone, Zhengzhou 451150, China; ³Beijing Key Laboratory of Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, China National Research Institute of Food and Fermentation Industries, Beijing 100015, China)

Abstract:

Fatty liver disease is currently one of the most common liver diseases in the world, and it has become the second largest liver disease after viral hepatitis. The incidence of fatty liver disease is increasing, and the age of onset is getting younger, which is a serious threat to human health. Fatty liver disease contains a series of pathological symptoms. As the disease progresses, patients may develop steatohepatitis, cirrhosis, and hepatocellular carcinoma. Generally speaking, fatty liver disease is a reversible disease, and early diagnosis and timely treatment can often lead to a return to normal. Cell model is an important way to study the pathological mechanism of fatty liver disease. In this paper, the pathogenesis of fatty liver disease is discussed, and the commonly used cell culture models in recent years are summarized and analyzed from the three aspects of cell type (primary hepatocytes of animals and humans, immortal cell lines, hepatocyte-like cells derived from induced pluripotent stem cells, and precision-cut liver slices), culture mode (monoculture, coculture, three-dimensional culture) and modeling method (high-fat, high-sugar and alcohol) used in the cell model. This will provide reference for the study of fatty liver disease and drug screening.

CSTR: 32200.14.cjcb.2020.12.0017