The Mechanism of Cognitive and Exercise Interventions on Prevention and Treatment of Alzheimer’s Disease
LI Wanyi1,2, GAO Junyan2, LIN Suyang2, LIU Zhitao1, WANG Qinwen2, LI Guangyu1*, LI Liping2*
AD (Alzheimer’s disease) is a clinically common neurodegenerative disorder that seriously threatens the aged people. However, the pathological mechanism of AD is still remain unclear and there are no effective treatment drugs. At present, a promising nonpharmacological therapy is attracting increasing attention. Accumulating evidence suggests that both exercise and cognitive interventions may be cost-effective strategies to ameliorate the pathological symptoms of AD. Cognitive intervention can delay the cognitive decline of AD patients and improve their stress responses to external events, while exercise intervention can reduce or delay the occurrences of AD by reducing excessive Aβ deposition and preventing the formation of hyperphosphorylated Tau protein, altering epigenetic modifications, promoting the release of neurotrophic factors and nerve growth factors, activating AMPK signaling pathway, as well as inhibiting inflammatory responses. This article reviews the curative effect and mechanism of cognitive and exercise interventions, hoping to provide a theoretical basis for the nonpharmacological therapy of those interventions to the AD patients.
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