The Application of Single-Cell Sequencing Technology in Reproductive Research
GAO Shanfeng1, XIAO Xuan1, ZHANG Lingyu1, NI Lei1, LIU Liying2, HAN Lin2, YANG Juan1*
Cell is the basic unit of life. Heterogeneity is one of the basic properties of cell. Getting the sequence and expression information at the single-cell level is of great significance for studying the new types of cells, ontogeny, organogenesis, disease development and the key signaling pathways. Nowadays, infertility and other diseases are being seriously with the increasing of pressure and social competition, which causes heavy burden to many families. The normal development of germ cells and embryos is the basic condition for reproduction. How to solve the problem of reproduction has become a research hot-spot. With the rapid development of sequencing technology as well as omics researches, single-cell sequencing technology provides a new method for reproductive researches, especially for germ cells and embryo cells with small sample sizes. In recent years, driven by single-cell sequencing technology, there have been many new advances in the field of reproduction research. The current review has summarized the development of single-cell sequencing technology and its application in the field of reproduction in recent years.
CN
EN