Research Progress of Circadian Clock Involved in Cellular Senescence
WEI Yu, WU Junhua*
Circadian clock is an endogenous regulatory system commonly found in the mammalian suprachiasmatic nucleus of hypothalamus and peripheral tissues, which makes the physiological activities and behaviors of organisms carry out the day-and-night cycle with the rotation of the earth for 24 h. In addition to regulating tissue development and the occurrence of diseases, circadian clock can also regulate cellular senescence by affecting cell cycle, intracellular reactive oxygen species and so on. In this paper, the mechanism of circadian clock involved in regulating cellular senescence is reviewed, and the cellular senescence-associated signaling pathways regulated by circadian clock are summarized to help to study the mechanism of cellular senescence in various aspects.
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